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The Chemistry and Biological Applications of 3 H‐ Pyrrolo[2,3‐ c ]quinolines and Marinoquinolines
Author(s) -
Dias do Espírito Santo Rafael,
Capitão Rebeca Monique,
Santos Barbosa Patrícia,
Simão dos Santos Eric Francisco,
Roque Duarte Correia Carlos
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100223
Subject(s) - quinoline , chemistry , antifungal , combinatorial chemistry , biological activity , stereochemistry , organic chemistry , biochemistry , microbiology and biotechnology , in vitro , biology
The heterocyclic 3 H ‐pyrrolo[2,3‐ c ]quinoline system and its closely related natural products, the marinoquinolines, have been attracting considerable attention in recent years in view of its interesting chemistry and diverse biological activities. Known since 1924, only in 2006 were the 3 H ‐pyrrolo[2,3‐ c ]quinolines associated with the first marinoquinolines isolated from natural sources. Their architecture and biological activities such as antiplasmodial, anti‐proliferative, anti‐bacterial, antifungal, phosphodiesterase and AChE inhibitors, and as ion‐sensing have stimulated the development of new strategies to obtain the natural marinoquinolines and new 3 H ‐pyrrolo[2,3‐ c ]quinoline derivatives. This review details the recent synthesis and biological evaluation of natural and unnatural marinoquinolines and its 3 H ‐pyrrolo[2,3‐ c ]quinoline core.