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Organocatalytic Enantioselective Desymmetrization of Prochiral 2,2‐Disubstituted Cyclic 1,3‐Diones
Author(s) -
Chegondi Rambabu,
Patel Srilaxmi M.,
Maurya Sundaram,
Donthoju Ashok
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100180
Subject(s) - desymmetrization , enantioselective synthesis , organocatalysis , chemistry , organic chemistry , catalysis , stereochemistry , combinatorial chemistry
Enantioselective desymmetrization of prochiral 1,3‐cyclodiketones is the most convenient and highly desired transformation to access densely functionalized, enantiomerically enriched scaffolds with multiple chiral centers. In recent years, organocatalysis has made significant progress in this research area along with other traditional metal‐ or enzyme‐catalyzed reactions. This mini‐review provides an overview of the recent developments in the domain of organocatalytic enantioselective desymmetrization along with a brief discussion about future perspectives.