Premium
Iridium Catalysed Asymmetric Allylic Substitution Reaction of Indolizine Derivatives
Author(s) -
Lu Jiamin,
Wang Meifang,
Xu Ruigang,
Sun Haizhou,
Zheng Xuan,
Zhong Guofu,
Zeng Xiaofei
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100171
Subject(s) - indolizine , chemistry , allylic rearrangement , stereoselectivity , iridium , combinatorial chemistry , catalysis , lewis acids and bases , substitution reaction , enantioselective synthesis , selectivity , organic chemistry
A highly efficient direct asymmetric allylic substitution (AAS) reaction of indolizine derivatives with allylic alcohols for accessing enantioenriched indolizine derivatives was realized by combining a chiral iridium complex catalyst with Lewis acid under mild reaction conditions, delivering various chiral allylation products in remarkably high yields and excellent enantioselectivities. This protocol distinguishes itself by availability of the starting materials, mild reaction conditions, broad substrate scope, high yields, excellent selectivity and easy scale‐up in a stereoselective manner, which provides a highly efficient protocol for chiral indolizines.