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Solvent‐Free Ruthenium‐Catalyzed Direct Coupling of Phosphines and Aryl Chlorides via C−H Activation: An Efficient and Straight Access to Aryl‐Substituted Biarylphosphines
Author(s) -
Zhang NiJuan,
Ma WenTao,
Li JiaWei,
Liu YueJin,
Zeng MingHua
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100161
Subject(s) - chemistry , aryl , phosphine , catalysis , ruthenium , combinatorial chemistry , reagent , palladium , solvent , selectivity , organic chemistry , medicinal chemistry , alkyl
Abstract An efficient and straightforward synthesis of aryl‐substituted biarylphosphines via unprotected amino acid‐accelerated ruthenium‐catalyzed P‐directed ortho ‐C−H arylation reaction is described. This protocol utilized commercial and inexpensive (hetero)aryl chlorides as efficient arylating reagents under solvent‐free reaction conditions. Notably, diverse aryl bromides were also effective for this transformation. With the protocol, a wide variety of mono‐arylated biarylphosphines were obtained in moderate to high yields and excellent selectivity. Moreover, the aryl‐substituted phosphine exhibited higher catalytic performance than its precursor and other substituted phosphines in palladium‐catalyzed Suzuki coupling.