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Carbene‐Catalyzed N , N ‐Nucleophilic Activation of Thioureas for Access to Pyrimidinthione Derivatives
Author(s) -
Cao Liya,
Li Tingting,
Chi Yonggui Robin,
Jin Zhichao
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100113
Subject(s) - chemistry , carbene , nucleophile , thiourea , cycloaddition , catalysis , ring (chemistry) , medicinal chemistry , substrate (aquarium) , combinatorial chemistry , organic chemistry , oceanography , geology
An N ‐heterocyclic carbene‐catalyzed [3+3] cycloaddition reaction of acylthioureas with ynals is reported. Both N atoms in the thiourea substrate are activated as nucleophiles and incorporated inside the ring system of the product. Pyrimidinthione derivatives bearing various substituents and substitution patterns are afforded as the products in moderate to good yields.