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Iron‐Catalyzed Oxidative Decabonylation/Radical Cyclization of Aliphatic Aldehydes with Biphenyl Isocyanides: A New Pathway For the Synthesis of 6‐Alkylphenanthridines
Author(s) -
Luo Zaigang,
Li Rui,
Zhu Tao,
Liu ChenFu,
Feng Haoran,
Aboagye Nartey Kojo,
Liu Qiannan,
Xu Xuemei
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100112
Subject(s) - chemistry , decarbonylation , catalysis , oxidative phosphorylation , biphenyl , alkyl , organic chemistry , radical cyclization , combinatorial chemistry , biochemistry
A facile and efficient synthetic approach to C6 functionalized phenanthridines was developed. The iron catalyzed oxidative reaction undergoes subsequent decarbonylation, radical addition and cyclization processes by using aliphatic aldehydes as the alkyl radical precursors. This protocol offers a new pathway for the synthesis of 6‐alkylphenanthridines.