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Synthesis of β‐Alkoxy Amines from Alkenes, Sulfonyl Azides, and Alcohols though Copper‐Catalyzed Three‐Component Tandem Reactions via Regioselective Ring‐Opening of Aziridine Intermediates
Author(s) -
Fu XiaoFei,
Zhao Qiang,
Zhao WenXian
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100087
Subject(s) - aziridine , chemistry , regioselectivity , sulfonyl , alkoxy group , catalysis , ring (chemistry) , organic chemistry , copper , combinatorial chemistry , cascade reaction , tandem , alkyl , materials science , composite material
A copper‐catalyzed three‐component tandem reaction of alkenes, sulfonyl azides, and alcohols is described. This straightforward transformation provides a practical method for the synthesis of valuable β‐alkoxy amines from easily accessible starting materials under comparative cheap copper catalysis without external ligands though regioselective ring‐opening reaction of aziridine intermediates. This reaction has a broad functional groups tolerance and the yields are generally good.