Premium
Asymmetric [3+2] Annulations of Thioaurone and Aurone Derivatives for the Construction of Spiroheterocycles
Author(s) -
Liu BaoXin,
Yan RuJie,
Li XiaoXun,
Du Wei,
Chen YingChun
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100078
Subject(s) - chemistry , benzothiophene , benzofuran , annulation , stereoselectivity , broad spectrum , enantioselective synthesis , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , thiophene
Aurones and their analogues are convenient two‐atom units for the rapid construction of valuable spiroheterocycles. Here, we demonstrate that the Morita–Baylis–Hillman carbonates of isatins can be efficiently assembled with thioaurones, aurones, or even methyleneindolinones in a highly asymmetric [3+2] annulation manner, affording a broad spectrum of densely functionalized spiro‐benzothiophene, ‐benzofuran and bisspirooxindole frameworks in high yields with good to excellent stereoselectivity.