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Ullmann‐Goldberg and Buchwald‐Hartwig C−N Cross Couplings: Synthetic Methods to Pharmaceutically Potential N‐Heterocycles
Author(s) -
Seifinoferest Behnoush,
Tanbakouchian Arezoo,
Larijani Bagher,
Mahdavi Mohammad
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100072
Subject(s) - chemistry , amination , pharmacophore , combinatorial chemistry , moiety , ullmann reaction , drug discovery , stereochemistry , organic chemistry , catalysis , biochemistry
The Carbon‐Nitrogen bond formation has always been an important and useful tool in drug discovery. Its wide applications in synthesizing N‐heterocycles, known as the most prevalent moiety in the active pharmacophores, have attracted increasing attention from researchers. In recent years many works were devoted to finding new and more rapid and effective chemo‐ and regio‐selective methods for the synthesis of N‐containing heterocycles. Buchwald‐Hartwig and Ullman‐Goldberg are two proven efficient methods for synthesizing five, six, and seven‐membered heterocycles found abundantly in literature. Here, we study these two amination methods more precisely, based on the reaction conditions and the products.