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Radical Annulation for the Synthesis of Cyclopenta[c]chromene Derivatives
Author(s) -
Mao Kaimin,
Dai Lei,
Chen Ang,
Liu Yun,
Liu Xiaoqin,
Wang Chang,
Rong Liangce
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100066
Subject(s) - chemistry , annulation , nitrile , functional group , combinatorial chemistry , phenol , substrate (aquarium) , methylene , organic chemistry , stereochemistry , catalysis , oceanography , geology , polymer
A Cu‐catalyzed oxidative radical [2+2+1] annulation reaction of phenol‐linked 1,7‐enynes with α ‐active methylene nitrile is described, affording cyclopenta[ c ]chromene derivatives bearing several functional groups in excellent yields. The wide substrate range, good group tolerance, and easy amplification experiments indicate the practicability of this synthesis strategy. This process provides an alternative convenient route for the synthesis of cyclopenta[ c ]chromene derivatives.