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Intermolecular Amination of Ketoximes with Anthranils by Rh‐Catalyzed C−H Bond Activation in Air
Author(s) -
Chen Weiqiang,
Li ChaoYi,
Li HuiJing,
Wu YanChao
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100043
Subject(s) - chemistry , amination , aryl , catalysis , intermolecular force , context (archaeology) , oxime , medicinal chemistry , chelation , organic chemistry , combinatorial chemistry , molecule , alkyl , paleontology , biology
The formation of C−N bonds is a fundamental bond construction in organic synthesis. In this context, a [RhCp*Cl 2 ] 2 /AgSbF 6 system was developed for the C2‐amination of ketoximes with anthranils with the use of Piv 2 O as a promoter. Piv 2 O played an important role in the generation of catalytically active species with [RhCp*Cl 2 ] 2 . The oxime unit was revealed to be effective chelating groups to activate the aryl C−H bond. The amination shows a wide substrates scope, and several important functional groups were tolerated under the benign reaction conditions.