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Palladium‐Phenylpyrazolylphosphine‐Catalyzed Cross‐Coupling of Alkenyl Pivalates
Author(s) -
Chen Zicong,
So Chau Ming
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100031
Subject(s) - palladium , chemistry , catalysis , phosphine , reagent , ligand (biochemistry) , coupling reaction , combinatorial chemistry , coupling (piping) , organic chemistry , receptor , engineering , mechanical engineering , biochemistry
Palladium‐catalyzed cross‐coupling reactions are indispensable tools for C−C bond formation, and new catalyst development remains a powerful driving force in this field. In this study, a new type of easily accessible phenylpyrazole phosphine ligand is developed. The catalyst generated from Pd(OAc) 2 and PP‐Phos ( L15 ) is highly effective in the palladium‐catalyzed cross‐coupling of alkenyl pivalates with organomagnesium reagents. The reaction accommodates a broad scope of alkenyl carboxylates under mild conditions, providing an alternative but practical way to the synthesis of multi‐substituted alkenes in value.