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Sequential One‐pot Method for the Synthesis of 4‐(Hydroxymethyl)oxazoles and their Application in Phosphonates Synthesis
Author(s) -
Kajol Km,
Ramesh Chintakunta
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000710
Subject(s) - hydroxymethyl , chemistry , combinatorial chemistry , substrate (aquarium) , scope (computer science) , reaction conditions , scalability , organic chemistry , catalysis , computer science , programming language , oceanography , database , geology
A sequential one‐pot method for the synthesis of 4‐(hydroxymethyl)oxazoles from readily available benzamides has been developed. Various substituted benzamides well‐tolerated and furnished 4‐(hydroxymethyl)oxazoles in moderate to good yields under the present reaction conditions. In order to demonstrate the usefulness of the present methodology, the resulting 4‐(hydroxymethyl)oxazoles were successfully transformed into its corresponding phosphonates under Michaelis‐Arbuzov reaction conditions. This methodology features a broad substrate scope, step economy, ease of execution, and scalability.