Visible‐Light‐Induced Radical Difluoromethylation of Alkynoates by [bis(Difluoroacetoxy)iodo]benzene to Yield 3‐Difluoromethylated Coumarins | Zendy

Lu Kui | Zendy; Zhou Ting | Zendy; Jia Xiaodong | Zendy; Wei Peng | Zendy; Lei Lingyu | Zendy; Xi Xiaolan | Zendy; Liu Jiang | Zendy; Zhao Xia | Zendy

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Visible‐Light‐Induced Radical Difluoromethylation of Alkynoates by [bis(Difluoroacetoxy)iodo]benzene to Yield 3‐Difluoromethylated Coumarins

Author(s) -

Lu Kui,

Zhou Ting,

Jia Xiaodong,

Wei Peng,

Lei Lingyu,

Xi Xiaolan,

Liu Jiang,

Zhao Xia

Publication year - 2021

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.202000655

Subject(s) - chemistry , yield (engineering) , benzene , catalysis , radical cyclization , medicinal chemistry , organic chemistry , combinatorial chemistry , materials science , metallurgy

A visible‐light‐induced radical difluoromethylation of alkynoates using [bis(difluoroacetoxy)iodo]benzene as the CF 2 H radical precursor was developed for the first time. 3‐Difluoromethyl‐substituted coumarins were synthesized via a radical difluoromethylation/cyclization/ester migration cascade. The mild and catalyst‐free conditions, as well as the good functional group tolerance, render this protocol an alternative and green strategy for the synthesis of 3‐difluoromethyl‐substituted coumarins.

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