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Advances in Base‐Mediated Post‐Ugi Transformations via Peptidyl Anion Trapping
Author(s) -
Ghoshal Anirban,
Ambule Mayur D.,
Yadav Anamika,
Srivastava Ajay Kumar
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000648
Subject(s) - chemistry , electrophile , intramolecular force , combinatorial chemistry , adduct , ugi reaction , amide , aldehyde , isocyanide , stereochemistry , computational chemistry , organic chemistry , catalysis
Advances in base‐mediated post‐Ugi transformations are reported and discussed. The minireview encompasses reports showing the abstraction of an alpha proton adjacent to amide carbonyl in aldehyde‐derived Ugi adducts under basic conditions to perform intramolecular and intermolecular cyclizations. The methodologies have been broadly classified depending on the peptidyl anion trapping under metal‐free, metal‐catalyzed, microwave‐assisted, and external electrophile‐aided reaction conditions. A comprehensive analysis of the methods has been presented, highlighting the importance in synthetic and medicinal chemistry.