Pd(II)‐catalyzed, Picolinamide‐aided sp 2  γ−C−H Functionalization of Phenylglycinol: Access to γ−C−H Arylated, Alkylated and Halogenated Phenylglycinol Scaffolds | Zendy

Singh Prabhakar | Zendy; Arulananda Babu Srinivasarao | Zendy; Aggarwal Yashika | Zendy; Patel Pooja | Zendy

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Pd(II)‐catalyzed, Picolinamide‐aided sp 2 γ−C−H Functionalization of Phenylglycinol: Access to γ−C−H Arylated, Alkylated and Halogenated Phenylglycinol Scaffolds

Author(s) -

Singh Prabhakar,

Arulananda Babu Srinivasarao,

Aggarwal Yashika,

Patel Pooja

Publication year - 2021

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.202000560

Subject(s) - chemistry , halogenation , catalysis , alkylation , surface modification , substrate (aquarium) , denticity , combinatorial chemistry , organic chemistry , medicinal chemistry , stereochemistry , crystal structure , oceanography , geology

We report the Pd(II)‐catalyzed picolinamide‐aided ortho ‐C−H arylation‐, alkylation‐, and halogenation (sp 2 γ −C−H functionalization) of phenylglycinol substrates. Phenylglycinols are remarkable building blocks and have found different applications in synthetic organic and medicinal chemistry. This work is a contribution towards the expansion of the library of phenylglycinol scaffolds and also substrate scope development by using the Pd(II)‐catalyzed bidentate directing group picolinamide‐aided C−H activation tactic.

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