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Pd(II)‐catalyzed, Picolinamide‐aided sp 2 γ−C−H Functionalization of Phenylglycinol: Access to γ−C−H Arylated, Alkylated and Halogenated Phenylglycinol Scaffolds
Author(s) -
Singh Prabhakar,
Arulananda Babu Srinivasarao,
Aggarwal Yashika,
Patel Pooja
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000560
Subject(s) - chemistry , halogenation , catalysis , alkylation , surface modification , substrate (aquarium) , denticity , combinatorial chemistry , organic chemistry , medicinal chemistry , stereochemistry , crystal structure , oceanography , geology
We report the Pd(II)‐catalyzed picolinamide‐aided ortho ‐C−H arylation‐, alkylation‐, and halogenation (sp 2 γ −C−H functionalization) of phenylglycinol substrates. Phenylglycinols are remarkable building blocks and have found different applications in synthetic organic and medicinal chemistry. This work is a contribution towards the expansion of the library of phenylglycinol scaffolds and also substrate scope development by using the Pd(II)‐catalyzed bidentate directing group picolinamide‐aided C−H activation tactic.