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Zwitterion‐Catalyzed Amino‐Dibromination of Nitroalkenes: Scope, Mechanism, and Application to The Synthesis of Glycinamides
Author(s) -
Ng WingHin,
Lam YingPong,
Hu RongBin,
Ng WingLok,
Yeung YingYeung
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000514
Subject(s) - zwitterion , chemistry , scope (computer science) , catalysis , combinatorial chemistry , amide , mechanism (biology) , organic chemistry , molecule , philosophy , epistemology , computer science , programming language
Glycinamides are valuable building blocks of natural products and biological relevant molecules. Many existing methods for the synthesis of glycinamides rely on harsh conditions. Herein, we report a zwitterion‐catalyzed aminobromination of nitroalkenes using N ‐bromosuccinimide as the Br source and the amide donor. The resulting aminobromide products are converted into glycinamides.