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Synthetic Approaches to the Anticancer Agent Fredericamycin A
Author(s) -
Kotha Sambasivarao,
Fatma Ambareen
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000484
Subject(s) - chemistry , total synthesis , stereocenter , annulation , ring closing metathesis , combinatorial chemistry , salt metathesis reaction , metathesis , stereochemistry , enantioselective synthesis , organic chemistry , catalysis , polymer , polymerization
In this minireview, we have highlighted various developments related to the total synthesis of an anticancer agent, fredericamycin A (NSC‐305263). The presence of a unique molecular architecture and significant biological properties associated with fredericamycin A have greatly enhanced the research activity, and we cover the total synthesis of this molecule since its isolation. Different methodologies adopted for the construction of the stereogenic spiro centre are radical spirocyclization, Diels−Alder (DA) reaction, [3+2] annulation, photochemical approach, ring‐closing metathesis (RCM), palladium‐catalyzed cross‐coupling reaction, rearrangement approach, benzannulation etc. This minireview provides an overview of the contribution of different research groups in the total synthesis of fredericamycin A. We also cover various model studies related to the synthesis of this molecule.