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Base‐Promoted Regiospecific Synthesis of Fully Substituted 1,2,3‐Triazoles and 1,5‐Disubstituted 1,2,3‐Triazoles
Author(s) -
Zhang Xueying,
Cui Xue,
Wang Wei,
Zeng Tingting,
Wang Yan,
Tan Yinfeng,
Liu Dongyan,
Wang Xuesong,
Li Youbin
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000479
Subject(s) - chemistry , diazo , cleavage (geology) , combinatorial chemistry , bond cleavage , stereochemistry , substrate (aquarium) , medicinal chemistry , catalysis , organic chemistry , oceanography , geotechnical engineering , fracture (geology) , engineering , geology
Abstract An efficient strategy have been developed for the synthesis of fully substituted 1,2,3‐triazoles and 1,5‐disubstituted 1,2,3‐triazoles subsequently by C−C bond cleavage. Regitz diazo‐transfer and C−C bond cleavage process were involved in this reaction to give 1,2,3‐triazoles with good substrate tolerance. This protocol provideed a facile and an expeditious approach for the assembly of diversely structural 1,2,3‐triazoles.