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RuCl 3 Catalyzed Reaction of Chromones with Bestmann‐Ohira Reagent for the Construction of 2‐Hydroxybenzoyl‐1 H ‐pyrazolylphosphonates and Dihydrochromeno[3,2‐ c ]pyrazolylphosphonates
Author(s) -
Kommera Rajkumar,
Balasubramanian Sridhar,
Raju Bhimapaka China
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000420
Subject(s) - chemistry , reagent , decarbonylation , catalysis , intramolecular force , medicinal chemistry , organic chemistry
A novel and efficient method has been developed for the synthesis of 2‐hydroxybenzoyl‐1 H ‐pyrazolylphosphonates and dihydrochromeno[3,2‐ c ]pyrazolylphosphonates by the reaction of 3‐formylchromones/3‐halo‐4 H ‐chromenones with Bestmann‐Ohira Reagent (BOR) in the presence of RuCl 3 catalyst. The reactions proceeded through decarbonylation, debromination, intramolecular cyclization and N ‐methylation to provide the new heterocyclic compounds in one‐pot with the formation of C−C and C−N bonds. The structure assignment of compound 3 f was confirmed by X‐ray analysis.