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Electrochemical Methods for Pd‐catalyzed C−H Functionalization
Author(s) -
Erchinger Johannes E.,
Gemmeren Manuel
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000372
Subject(s) - chemistry , surface modification , catalysis , electrochemistry , combinatorial chemistry , palladium , atom economy , toolbox , stoichiometry , nanotechnology , organic chemistry , materials science , electrode , computer science , programming language
The activation and functionalization of C−H bonds using palladium catalysts has become an important part of a modern chemist toolbox, as it enables a range of highly useful transformations to be achieved in a single synthetic step. However, many established protocols for such C−H functionalizations rely on stoichiometric amounts of chemical oxidants, which are often expensive and/or toxic, and lower the atom efficiency. Striving for more sustainable transformations, electrochemistry has re‐emerged as an alternative atomless approach towards oxidation, potentially offering cheap and more user‐friendly methodologies. Herein we discuss recent endeavors to combined electrochemistry and Pd‐catalyzed C−H activation/functionalization, to achieve C−C, C−X, C−O and C−P bond formation.