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Phosphine‐Catalyzed δ‐Addition Reaction of γ‐Substituted Allenoates with Isatin Derivatives
Author(s) -
Wu Lulu,
Chen Kaihong,
Huang You,
Li ErQing
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000246
Subject(s) - isatin , phosphine , chemistry , synthon , catalysis , oxindole , combinatorial chemistry , organic chemistry , nitroaldol reaction , enantioselective synthesis
A novel phosphine‐catalyzed δ‐addition reaction between allenoates and isatin derivatives has been developed. In this reaction, γ‐substituted allenoates were used as a novel C 1 synthon to produce oxindole derivatives in good yields and highly diastereoselectivities. Based on the previous mechanistic studies, a proposed phosphine‐catalyzed δ‐addition reaction has been outlined.
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