Premium
Transition‐Metal‐Mediated/Catalyzed Synthesis of Pyridines, Pyrimidines, and Triazines by [2+2+2] Cycloaddition Reactions
Author(s) -
Nagata Tatsuki,
Obora Yasushi
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000240
Subject(s) - chemistry , cycloaddition , catalysis , transition metal , nitrile , triazine , combinatorial chemistry , selectivity , metal , organic chemistry
Abstract Nitrogen‐containing six‐membered heterocycles such as pyridines, pyrimidines, and triazines are widely used in the synthesis of natural products and pharmaceuticals. Recently, a promising approach to these structures via [2+2+2] cycloadditions of alkynes and nitriles has been developed. Transition‐metal complex catalysts play key roles in the regio‐, chemo‐, or stereo‐selectivity of transformations. Here, we summarize recent advances in metal‐mediated/catalyzed [2+2+2] cycloadditions for synthesizing pyridines and pyrimidines. We also describe progress in triazine synthesis via metal‐mediated/catalyzed nitrile cyclotrimerization.