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Indazolone‐Assisted Sequential ortho ‐Alkenylation‐Oxidative Aza‐Michael Addition of 1‐Arylindazolone Using Acrylates Under Ru(II) Catalysis
Author(s) -
Mahesha Chikkagundagal K.,
Mandal Sanjay K.,
Sakhuja Rajeev
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000239
Subject(s) - chemistry , intramolecular force , moiety , catalysis , oxidative phosphorylation , michael reaction , functional group , annulation , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , polymer
A one‐pot annulation of 1‐arylindazolones and acrylates is achieved through Ru(II)‐catalyzed sequential ortho ‐alkenylation followed by oxidative intramolecular aza‐Michael addition reaction to deliver substituted indazolo[1,2‐ a ]indazolylidenes in good‐to‐excellent yields. The strategy showcased high functional group tolerance and the directing group ability of indazolone moiety was established for Csp 2 ‐H bond activation.