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Efficient Cu‐catalyzed Synthesis of Benzimidazoles Using Ammonia as Nitrogen Source in Water
Author(s) -
Li Minxin,
Tang Yanling,
Gao Hui,
Rao Gaoxiong,
Mao Zewei
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000236
Subject(s) - chemistry , catalysis , functional group , ammonia , solvent , condensation , reaction conditions , organic chemistry , nitrogen , combinatorial chemistry , ammonia production , green chemistry , ullmann reaction , reaction mechanism , physics , thermodynamics , polymer
In present work, we have developed an efficient strategy for the synthesis of 2‐substituted benzimidazoles via Cu‐catalyzed Ullmann condensation reaction of o ‐halobenzanilides with ammonia in water. This protocol is applicable to a wide variety of 2‐substituted benzimidazoles bearing functional groups tolerance, which features one‐pot, high yields, functional groups tolerable and green solvent.