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Cover Feature: Noncovalent Chalcogen‐Bonding Catalysis Using ppm‐Level Catalyst Loading to Achieve Cyanosilylation of Ketones (Asian J. Org. Chem. 5/2020)
Author(s) -
Bao Lintao,
Kong Xiangjin,
Wang Yao
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000216
Subject(s) - chalcogen , catalysis , chemistry , non covalent interactions , organocatalysis , combinatorial chemistry , nanotechnology , organic chemistry , hydrogen bond , molecule , enantioselective synthesis , materials science
As noncovalent chalcogen‐bonding interaction is comparatively weak, it remains a true challenge to implement chalcogen‐bonding catalysis in an efficient manner. Enabled by a class of extraordinary catalysts, it was demonstrated that a dual chalcogen‐bonding catalysis approach to the cyanosilylation of ketones can be achieved even using as low as ppm‐level catalyst loading while the reactions were completed within several minutes. This extremely efficient catalysis approach shows the unique advantage of chalcogen‐bonding interactions and demonstrates the potential of this catalysis concept. More information can be found in the Communication by Yao Wang et al.