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Auto‐Oxidative Povarov/Aromatization Tandem Reaction of Glycine Derivatives with Enamides: Acylamino as both Activating and Leaving Group
Author(s) -
Huang Songhai,
Bao Xiazhen,
Fu Ying,
Zhang Yongxin,
Quan Zhengjun,
Huo Congde
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000191
Subject(s) - aromatization , chemistry , glycine , tandem , quinoline , leaving group , oxidative phosphorylation , cascade reaction , functional group , brønsted–lowry acid–base theory , catalysis , aryl , organic chemistry , combinatorial chemistry , medicinal chemistry , amino acid , biochemistry , polymer , materials science , alkyl , composite material
The auto‐oxidative Povarov/aromatization tandem reaction of N‐aryl glycine derivatives with enamides yields a series of complex quinoline derivatives in good yields. The reactions are performed using only catalytic amount of Brønsted acid and O 2 . The acylamino group is used as both activating and leaving group to improve the reaction efficiency in this transformation.