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Site‐Selective Trifluoromethylation Reactions of Oligopeptides
Author(s) -
Guerrero Itziar,
Correa Arkaitz
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000170
Subject(s) - trifluoromethylation , chemistry , peptidomimetic , amino acid , combinatorial chemistry , oligopeptide , peptide , amino acid residue , sequence (biology) , computational biology , trifluoromethyl , peptide sequence , biochemistry , organic chemistry , gene , biology , alkyl
Site‐selective chemical modifications that target proteinogenic amino acid residues complement the methods entailing genetic manipulation, thereby allowing straightforward and rapid access to engineered proteins. The incorporation of the trifluoromethyl group into amino acids within a peptide sequence results in relevant peptidomimetics with unique biomedicinal properties. As a result, the last decade has witnessed the development of a powerful set of protocols toward the selective trifluoromethylation of small‐to‐medium size peptides and proteins in a late‐stage fashion. This minireview seeks to highlight those particularly compelling cases published in the last years.