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Copper‐Catalyzed C−S Coupling of Quaternary Ammonium Salts and Dialkylcarbamodithioic Acid Salts
Author(s) -
Chen Hongyi,
Zhang Qiaoling,
Zheng Wenting,
Yang Hongqin,
Zeng Qingle
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000163
Subject(s) - chemistry , ammonium , catalysis , alkyl , coupling (piping) , copper , quaternary , enantioselective synthesis , organic chemistry , medicinal chemistry , mechanical engineering , paleontology , engineering , biology
Abstract An efficient synthesis of (chiral) alkyl dialkylcarbamodithioates via a CuI‐catalyzed C−S cross‐coupling reaction of (chiral) quaternary ammonium salts and (chiral) dialkylcarbamodithioic acid salts has been developed. C−S coupling products were obtained with extremely high ee values and yields, with enantioenriched arylmethyl trimethylammonium triflates affording the inverse absolute configuration.