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Synthesis of cis β‐Hydroxy Ketones by Desymmetrization of 1,3‐Cyclopentanediones through Ruthenium‐Catalyzed Hydrogen Transfer
Author(s) -
Wang Han,
Zhao Yang,
Ding YiXuan,
Yu ChangBin,
Zhou YongGui
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000121
Subject(s) - desymmetrization , chemistry , ruthenium , catalysis , reactivity (psychology) , transfer hydrogenation , combinatorial chemistry , enantioselective synthesis , organic chemistry , hydrogen , medicine , alternative medicine , pathology
A facile synthesis of chiral cis β‐hydroxy ketones was successfully developed through ruthenium‐catalyzed transfer hydrogenative desymmetrization of 1,3‐cyclopentanedione. The experiment on gram scale could be performed without loss of reactivity and enantioselectivity.