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Cover Feature: Iron‐Catalyzed Asymmetric Inter‐ and Intramolecular Aerobic Oxidative Dearomatizing Spirocyclization of 2‐Naphthols (Asian J. Org. Chem. 3/2020)
Author(s) -
Oguma Takuya,
Doiuchi Daiki,
Fujitomo Chisaki,
Kim Chungsik,
Hayashi Hiroki,
Uchida Tatsuya,
Katsuki Tsutomu
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000094
Subject(s) - chemistry , enantioselective synthesis , intramolecular force , catalysis , electrophile , nucleophile , molecular oxygen , oxidative phosphorylation , combinatorial chemistry , electron acceptor , stereochemistry , photochemistry , organic chemistry , biochemistry
Iron–salan complexes have led to highly chemo‐ and enantioselective inter‐ and intra‐molecular oxidative spirocyclization of arenols. Under the iron‐catalyzed oxidation conditions, arenols were oxidized to electrophilic radical intermediates in a chemoselective manner via single electron transfer and relating enantioselective nucleophilic dearomatizing cyclization to form spirocyclic compounds. The reaction can use molecular oxygen, the most abundant and ubiquitous hydrogen acceptor on Earth, as the oxidant. It is thought that these results are important knowledge for the development of iron catalysis. More information can be found in the Full Paper by Tatsuya Uchida et al. on page 404 in Issue 3, 2020 (DOI: 10.1002/ajoc.201900602).