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Transition‐Metal‐Free Selective C(sp 3 )−H Thiolation of Arylacetamides with Substituted Benzenethiols, Aryl Sulfenylchlorides and Diaryl Disulfides
Author(s) -
Liu Changying,
Li Zheyu,
Weng Zhengyun,
Fang Xinyue,
Zhao Fei,
Tang Kehui,
Chen Jianyang,
Ma Wenbo
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000083
Subject(s) - chemistry , aryl , transition metal , catalysis , acetic acid , substrate (aquarium) , metal , combinatorial chemistry , organic chemistry , oceanography , alkyl , geology
A synthetic method for the preparation of unsymmetrical 2‐arylthioacetamides though direct C(sp 3 )−H thiolation of arylacetamides with readily available substituted thiols, sulfenylchlorides and disulfides have been developed. Our strategy features a green reaction medium with ample substrate scope, affording the mono‐thiolated aryl acetic acid derivatives in moderate to good yields in the presence of weak bases without any transition‐metal catalyst.