Premium
Asymmetric Epoxidation of α,β‐Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)‐3,4‐Diaminopyrrolidine Derived N4‐Ligands with Camphorsulfonyl Sidearms
Author(s) -
Li Yuanfeng,
Zhang Yuecheng,
Zhang HongYu,
Han YaPing,
Zhao Jiquan
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000070
Subject(s) - chemistry , catalysis , enantioselective synthesis , stereochemistry , organic chemistry , medicinal chemistry
Three (R,R)‐3,4‐diaminopyrrolidine‐based chiral N 4 ligands and corresponding iron complexes were synthesized. The complexes were applied to the asymmetric epoxidation of various α,β‐unsaturated ketones with H 2 O 2 as an oxidant and carboxylic acid as auxiliary. Good to excellent enantioselectivity (up to 97%) was achieved in the case of 2,2‐dimethylbutyric acid as an auxiliary.