Asymmetric Epoxidation of α,β‐Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)‐3,4‐Diaminopyrrolidine Derived N4‐Ligands with Camphorsulfonyl Sidearms | Zendy

Li Yuanfeng | Zendy; Zhang Yuecheng | Zendy; Zhang HongYu | Zendy; Han YaPing | Zendy; Zhao Jiquan | Zendy

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Asymmetric Epoxidation of α,β‐Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)‐3,4‐Diaminopyrrolidine Derived N4‐Ligands with Camphorsulfonyl Sidearms

Author(s) -

Li Yuanfeng,

Zhang Yuecheng,

Zhang HongYu,

Han YaPing,

Zhao Jiquan

Publication year - 2020

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.202000070

Subject(s) - chemistry , catalysis , enantioselective synthesis , stereochemistry , organic chemistry , medicinal chemistry

Three (R,R)‐3,4‐diaminopyrrolidine‐based chiral N 4 ligands and corresponding iron complexes were synthesized. The complexes were applied to the asymmetric epoxidation of various α,β‐unsaturated ketones with H 2 O 2 as an oxidant and carboxylic acid as auxiliary. Good to excellent enantioselectivity (up to 97%) was achieved in the case of 2,2‐dimethylbutyric acid as an auxiliary.

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