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A Combination of Biocompatible Room Temperature Ionic Liquid and Palladium Catalyst for Base‐ and Ligand‐Free Suzuki Coupling Reactions
Author(s) -
Joo SeongRyu,
Kwon GyuTae,
Kim SeungHoi
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000059
Subject(s) - chemistry , ionic liquid , catalysis , ligand (biochemistry) , aryl , palladium , coupling reaction , hydroxide , halide , base (topology) , green chemistry , organic chemistry , suzuki reaction , combinatorial chemistry , polymer chemistry , inorganic chemistry , mathematical analysis , biochemistry , alkyl , receptor , mathematics
A system with mild and versatile reaction conditions for a carbon–carbon bond‐forming reaction using arylboronic acids and aryl halides was developed. A readily available and biodegradable room‐temperature ionic liquid, choline hydroxide (ChOH), was combined with a ligand‐free Pd(OAc) 2 ‐catalyst, providing the corresponding symmetrical and/or unsymmetrical biaryl products in satisfactory yields under aerobic conditions. No external base or ligand was required for completion of the cross‐coupling reactions. More significantly, the reaction medium showed good recyclability, which is an important characteristic from the viewpoint of sustainable chemistry.