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[3+2] Cycloaddition of Trifluoromethylated N ‐Acylhydrazones with Azomethine Ylides: Synthesis of Trifluoromethylated Imidazolidines
Author(s) -
Zhao Fangxia,
Wang KeHu,
Wen Lan,
Zhao Zhuanxia,
Hu Yongqin,
Xu Weigang,
Huang Danfeng,
Su Yingpeng,
Wang Junjiao,
Hu Yulai
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000057
Subject(s) - chemistry , trifluoromethyl , cycloaddition , organic chemistry , combinatorial chemistry , 1,3 dipolar cycloaddition , stereochemistry , catalysis , alkyl
Trifluoromethylated N‐ acylhydrazones are used as dipolarophiles to perform 1,3‐dipolar cycloadditions with azomethine ylides to afford trifluoromethylated 1,2,4,5‐tetrasubstituted imidazolidines in good yields under mild conditions. The role switch of the trifluoromethylated N ‐acylhydrazones demonstrates that they are versatile trifluoromethyl building blocks for CF 3 ‐containing heterocycles.