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Efficient Reduction of Oxazolyl‐Bearing Secondary Anilides to Amines by Nickel‐Catalyzed Hydrosilylation
Author(s) -
Zhou Jian,
Bo Xiaofan,
Wan Li,
Xin Zhong
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000054
Subject(s) - hydrosilylation , chemoselectivity , chemistry , nitro , catalysis , nickel , combinatorial chemistry , organic chemistry , alkyl
Abstract A convenient procedure for the catalytic hydrosilylation of secondary anilides bearing an oxazolyl group has been developed. In the presence of inexpensive NiBr 2 , the reduction of functionalized secondary amides with nontoxic and air‐stable TMDS proceeded smoothly to give the corresponding functionalized amines. The method displays a broad applicability for the reduction of many types of substrates, and shows good compatibility and excellent chemoselectivity for several sensitive functional groups such as halo, ester and nitro groups.