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π‐Conjugated Triazenes and Nitriles: Simple Photoinduced Synthesis of Anilides Using Mild and Metal‐Free Conditions
Author(s) -
Barragan Enrique,
NoonikaraPoyil Anurag,
Bugarin Alejandro
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000047
Subject(s) - chemistry , conjugated system , aryl , combinatorial chemistry , amide , photochemistry , organic chemistry , polymer , alkyl
Metal‐free, compatible and synchronized aryl–aryl cross‐coupling and amide bond formation reactions were accomplished in a single step using π‐conjugated triazenes as the versatile starting materials. This simple, mild, and direct photochemical approach afforded anilides in good to excellent yields (up to 99%). Interestingly, natural sunlight is also shown to provide effective delivery of amides at ambient temperature. The successful synthesis of an immunosuppressant and the commercial drug acetaminophen validates this methodology. More information can be found in the Full Paper by Enrique Barragan, Anurag Noonikara‐Poyil, and Alejandro Bugarin.