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Palladium‐Catalyzed Cascade Cyclization/Alkynylation of Alkene‐Tethered Carbamoyl Chlorides with Terminal Alkynes: Synthesis of Alkyne‐Functionalized Oxindoles
Author(s) -
Sun Wan,
Shi Xiaonan,
Chen Chen,
Zhu YanPing,
Liu Zhengyu,
Zhu Bolin
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000033
Subject(s) - chemistry , alkyne , alkene , alkynylation , propargyl , palladium , catalysis , cascade , combinatorial chemistry , cascade reaction , functional group , organic chemistry , chromatography , polymer
We reported the first palladium‐catalyzed copper‐free cascade cyclization/alkynylation of alkene‐tethered carbamoyl chlorides with terminal alkynes, which provided an alternative approach to synthesize various functionalized oxindoles bearing a propargyl all‐carbon quaternary center. This protocol was highly efficient and exhibited good functional group compatibility, as well as the broad substrate scope.