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Palladium‐Catalyzed Regioselective C−H Arylation of Quinoline‐ N ‐Oxides at C‐8 Position using Diaryliodonium Salts
Author(s) -
Sharma Shivani,
Kumar Sehdev,
Sharma Anuj
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000028
Subject(s) - quinoline , chemistry , regioselectivity , palladium , catalysis , aryl , combinatorial chemistry , derivative (finance) , oxide , medicinal chemistry , organic chemistry , alkyl , financial economics , economics
A simple and efficient Pd(II)‐catalyzed site‐selective direct arylation strategy was demonstrated for the synthesis of 8‐arylquinoline‐ N ‐oxide derivatives using quinoline‐ N ‐oxides and (aryl)(mesityl)iodonium triflates. A series of control experiments were carried out to elucidate the reaction mechanism. The synthetic potential was extended with the C‐2 post‐modification of the final derivative.