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Rhodium‐Catalyzed Direct ortho C−H Thiolation of Cyclic N ‐Sulfonyl Ketimines
Author(s) -
Shi Guangrui,
Khan Ruhima,
Zhang Xuexin,
Yang Yong,
Zhan Yong,
Li Juan,
Luo Yang,
Fan Baomin
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000017
Subject(s) - sulfonyl , chemistry , trifluoromethanesulfonate , rhodium , catalysis , substrate (aquarium) , surface modification , toluene , combinatorial chemistry , organic chemistry , medicinal chemistry , polymer chemistry , alkyl , oceanography , geology
An efficient method for the synthesis of thiolated cyclic N ‐sulfonyl ketimines has been developed. The reaction proceeds via rhodium catalyzed C−H functionalization using disulfides in the presence of silver carbonate, silver triflate and copper acetate in toluene. The methodology showed broad substrate scope as a wide range of N ‐sulfonyl ketimines participated in the reaction giving the thiolated products in up to 95%.