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Copper‐Catalyzed Cross‐Coupling of Benzylic Bromides with Arylboronic Acids: Synthesis of Diarylalkanes and Preliminary Antifungal Evaluation Against Magnaporthe Grisea
Author(s) -
Zhu Zhu,
Liu Jinggong,
Dong Shoucheng,
Chen Bolai,
Wang Zhenghui,
Tang Riyuan,
Li Zhaodong
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000007
Subject(s) - chemistry , magnaporthe grisea , antifungal , catalysis , copper , functional group , combinatorial chemistry , fungicide , propargyl , organic chemistry , stereochemistry , microbiology and biotechnology , botany , biochemistry , biology , oryza sativa , gene , polymer
Reported herein is the practical synthesis of 1,1‐diarylalkanes motifs via copper‐catalyzed cross‐coupling reaction of benzylic bromides with arylboronic acids under mild conditions. The protocols show broad scope and good functional group tolerance, and are also applicable to complex natural products. Mechanistic study indicates a radical mechanism. Moreover, preliminary antibacterial evaluation against Magnaporthe grisea is also described for the first time.