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Nickel‐Catalyzed 1,1‐Difluoroethylation of (Hetero)aryl Halides with 1,1‐Difluoroethyl Chloride (CH 3 CF 2 Cl)
Author(s) -
Liu Jianchang,
Zhang Jida,
Li Xiangye,
Wu Chaolin,
Liu Hefu,
Liu Hui,
Sun Fenggang,
Li Yueyun,
Liu Yuying,
Li Xinjin
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202000004
Subject(s) - chemistry , halide , aryl , nickel , catalysis , medicinal chemistry , chloride , aromaticity , inert , organic chemistry , molecule , alkyl
1,1‐Difluoroethylated aromatic compounds are of increasing importance in agrochemicals and pharmaceuticals. The direct introduction of difluoroethyl (CF 2 CH 3 ) group(s) onto aromatic rings using CH 3 CF 2 Cl, an inexpensive and available raw material, still remains a great challenge because of the relatively inert C−Cl bond of CH 3 CF 2 Cl. Herein, we disclose a nickel‐catalyzed 1,1‐difluoroethylation of (hetero)aryl halides with CH 3 CF 2 Cl. The reaction exhibits good functional‐group tolerance and is regarded as a practical method for synthesis of (1,1‐difluoroethyl)arenes.