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Synthesis of Spiroguanidine Derivatives by Dearomative Oxidative Cyclization using Hypervalent Iodine Reagent
Author(s) -
Odagi Minami,
Okuda Kazuma,
Ishizuka Hayate,
Adachi Kanna,
Nagasawa Kazuo
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900726
Subject(s) - hypervalent molecule , chemistry , iodine , reagent , benzene , intramolecular force , phenols , oxidative phosphorylation , phenol , combinatorial chemistry , organic chemistry , iodine compounds , medicinal chemistry , biochemistry
We have developed a versatile synthetic method for the construction of spirocyclic guanidines in moderate yields by intramolecular dearomative oxidative cyclization of guanidino phenols using the hypervalent iodine reagent 4‐chloro‐1‐(diacetoxyiodo)benzene in 2,2,3,3‐tetrafluoro‐1‐propanol.