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Acid‐Catalyzed Pseudo Five‐Component Annulation for a General One‐Pot Synthesis of 2,4,6‐Triaryl Pyrimidines
Author(s) -
Ding Yuxin,
Ma Renchao,
Hider Robert C.,
Ma Yongmin
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900700
Subject(s) - annulation , chemistry , catalysis , ketone , pyrimidine , component (thermodynamics) , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , physics , thermodynamics
A facile and general synthesis of 2,4,6‐triaryl pyrimidines has been developed. It involves a one‐pot [2+1+1+1+1] pseudo five‐component annulation of one methyl ketone, two aldehydes and two NH 4 OAc catalyzed by TfOH. One C−C and four C−N bonds are formed during the oxidative annulation process. The reaction shows good tolerance of many important functional groups in air and produces only water as the coproduct, making this methodology a highly versatile alternative to the existing methods for structuring pyrimidine framework.