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N‐Heterocyclic Carbene‐Catalyzed Activation of Ynals for the Construction of Functional Pyridines
Author(s) -
Li JiaHui,
Duan XiaoYong,
Tian ZhaoHui,
Zheng YiFan,
Qi Jing
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900693
Subject(s) - chemistry , carbene , pyridine , nucleophile , substituent , catalysis , combinatorial chemistry , organic chemistry , stereochemistry , medicinal chemistry
N‐heterocyclic carbene‐catalyzed activation of ynals for rapid synthesis of pyridine derivatives with important utilities has been reported. This successful strategy using NHC‐bound alkynyl acyl azolium as the key intermediate further improved the application of N ‐Ts 2‐aminoacrylate as a nucleophile. Importantly, this work introduces an ester substituent to pyridines that could be easily transformed to other functional groups.