Premium
Thioamidation of Arylpropyne Derivatives with Sulfur and Formamides for the Synthesis of Aryl Propanethioamides
Author(s) -
Xu HongHui,
Zhang XingGuo,
Zhang XiaoHong
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900680
Subject(s) - formamides , chemistry , aryl , sulfur , triple bond , hydrolysis , organic chemistry , combinatorial chemistry , double bond , formamide , alkyl
An efficient synthesis of aryl propanethioamides by a three‐component reaction of arylpropynes, elemental sulfur and formamides has been developed. The cascade thioamidation proceeds smoothly through the hydrolysis of the C−C triple bond and formamides, the formation of C−N bond and C−S double bond in one‐pot reaction.