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Synthesis of Nitrated N ‐Alkyl Anilines Using N ‐Nitroso Anilines as a Self‐Providing Nitro Group Source
Author(s) -
Zhang Yuxian,
Zhang Shuwei,
Sun Zheng,
Yuan Yu,
Jia Xiaodong
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900664
Subject(s) - chemistry , nitration , nitro , alkyl , nitroso , amine gas treating , group (periodic table) , aniline , nitroso compounds , organic chemistry , nitro compound , medicinal chemistry
In the presence of dioxygen, an efficient synthesis of nitrated N‐alkyl anilines was realized using N‐nitroso anilines as the starting material. According to the mechanistic study, the N‐nitroso anilines served as a self‐providing nitro group source to promote the direct nitration of N‐alkylanilines, avoiding the undesired protection of amine group.