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Rapid and Efficient Construction of Indolizino[3,4,5‐ ab ]isoindole Skeletons by a Rhodium‐Catalyzed Tandem Reaction
Author(s) -
Liu Chang,
Wu Shaonan,
Sun Wan,
Meng Haifang,
Xing Siyang,
Zhu Bolin
Publication year - 2020
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900660
Subject(s) - chemistry , isoindole , rhodium , aromatization , tandem , cycloaddition , catalysis , molecule , stereochemistry , medicinal chemistry , organic chemistry , materials science , composite material
A facile rhodium‐catalyzed tandem reaction of two molecules of acrylates with two molecules of 2‐phenylpyridines involving sequential C−H activation, Michael addition, [12+2] cycloaddition and oxidative aromatization has been described. A series of indolizino[3,4,5‐ ab ]isoindole compounds were efficiently afforded in good yields by the formation of two C−C bonds, two C=C bonds and one C−N bond.
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