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Rhodium‐Catalyzed Cascade Radical Cyclization of 1,6‐Enynes with Br−CX 3 : Access to Bromine‐Containing Trihalomethylated Pyrrolidines
Author(s) -
Zhang Yingying,
Chen Chen,
Zhao Jinghui,
Liu Guiyan
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900644
Subject(s) - chemistry , rhodium , bromine , enyne , cascade , catalysis , combinatorial chemistry , medicinal chemistry , radical cyclization , stereochemistry , organic chemistry , chromatography
We describe a novel rhodium(I)‐catalyzed cascade radical cyclization of 1,6‐enynes with Br−CX 3 (X=Cl,Br). This transformation presents an efficient method for the construction of a variety of bromine‐containing trihalomethylated pyrrolidines in moderate to good yields. A possible radical pathway is proposed based on the relevant literature and control experiments. Moreover, this protocol is also applicable to 1,7‐enyne analogues.