1,3‐Dipolar Cycloadditions of β‐Fluoroalkyl Vinylsulfones and Nitrile Oxides for Fluoroalkylated Isoxazolines and Isoxazoles | Zendy

Ou Zhi | Zendy; Huang Qian | Zendy; Kou YingDa | Zendy; Cheng Feng | Zendy; Kalita Subarna Jyoti | Zendy; Zhao ZhenNi | Zendy; Huang YiYong | Zendy

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1,3‐Dipolar Cycloadditions of β‐Fluoroalkyl Vinylsulfones and Nitrile Oxides for Fluoroalkylated Isoxazolines and Isoxazoles

Author(s) -

Ou Zhi,

Huang Qian,

Kou YingDa,

Cheng Feng,

Kalita Subarna Jyoti,

Zhao ZhenNi,

Huang YiYong

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201900578

Subject(s) - chemistry , nitrile , yield (engineering) , organic chemistry , polymer chemistry , medicinal chemistry , combinatorial chemistry , metallurgy , materials science

The 1,3‐dipolar cycloadditions of β‐fluoroalkyl vinylsulfones and nitrile oxides to deliver 5‐fluoroalkyl‐3‐substituted 2‐isoxazolines has been established under mild conditions in up to 85% yield with excellent regio‐ and diastereoselectivities (all d.r. >99 : 1), and thus facilitated rapid access to 5‐fluoroalkyl‐3‐Ph‐2‐isoxazoles by DBU‐mediated elimination of the pyridyl sulfone group.

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